NCT07748130
CoQ10 Effects on MDM Liver Fat Via FibroTouchI.
레지스트리 요약
- 진행 상태
- 모집 전 (NOT_YET_RECRUITING)
- 질환/조건
- Mitochondrial Diabetes
- 시험 유형
- 중재 연구 (INTERVENTIONAL)
- 단계
- 해당 없음(NA)
- 목적
- 치료
- 중재 유형
- 약물, 기타
- 개입·치료
- Coenzyme Q10 (drug), Only undergo baseline assessments without intervention., Only undergo baseline assessments without intervention.
- Lead Sponsor
- The 95th Hospital of Putian，Putian, Fujian, China (기타)
캐시 시각: 2026-08-06 10:05:26
요약
Mitochondrial diabetes mellitus (MDM) is a rare subtype of diabetes caused by mitochondrial dysfunction, often accompanied by hepatic steatosis. Coenzyme Q10 (CoQ10), a key electron carrier and antioxidant, may improve mitochondrial function and lipid metabolism. This prospective study aims to evaluate the effect of 12-week CoQ10 supplementation (300 mg/day) on liver fat content (assessed by FibroTouch CAP ) in MDM patients with m.3243A\>G mutation. An exploratory case-control design will compare baseline characteristics among MDM patients, type 1 diabetes patients, and healthy controls. This study is the first to explore the link between mitochondrial defects and hepatic fat accumulation specifically in MDM, and to test CoQ10 as a potential therapy, offering new insights for both MDM and MAFLD management.
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