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NCT05413343

Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients

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레지스트리 요약

진행 상태: 완료 (COMPLETED)
질환/조건: Severe Sepsis, Carbapenem Resistant Bacterial Infection
시험 유형: 관찰 연구 (OBSERVATIONAL)
중재 유형: 약물
개입·치료: Ceftazidime-avibactam
Lead Sponsor: First Affiliated Hospital of Zhejiang University (기타)

캐시 시각: 2026-09-10 23:27:16

ClinicalTrials.gov에서 보기

요약

This prospective observational study is conducted at the First Affiliated Hospital of Zhejiang University School of Medicine from June 1, 2021 to January 1, 2024. The study aims to characterize the population pharmacokinetics of ceftazidime (CAZ) and avibactam (AVI) in critically ill patients receiving ceftazidime-avibactam (CAZ-AVI), including patients with and without renal replacement therapy (RRT). Plasma concentrations of CAZ and AVI will be measured after the first-dose and steady-state administrations. Population pharmacokinetic and pharmacokinetic/pharmacodynamic target-attainment analyses will be performed to explore dosing strategies according to renal function and RRT status.

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