NCT07332507
Testing the Effect of Teclistamab on Recurrent Plasmablastic Lymphoma
레지스트리 요약
- 진행 상태
- 모집중 (RECRUITING)
- 질환/조건
- Recurrent Plasmablastic Lymphoma, Refractory Plasmablastic Lymphoma
- 시험 유형
- 중재 연구 (INTERVENTIONAL)
- 단계
- Phase 1
- 목적
- 치료
- 중재 유형
- 시술·수술, 약물
- 개입·치료
- Biospecimen Collection, Computed Tomography, Positron Emission Tomography, Teclistamab
- Lead Sponsor
- National Cancer Institute (NCI) (NIH)
캐시 시각: 2026-07-25 04:09:39
요약
This phase Ib trial tests the safety, side effects, and best dose of teclistamab in treating patients with plasmablastic lymphoma that has come back after a period of improvement (recurrent) or that has not responded to previous treatment (refractory). Teclistamab is a bispecific antibody that can bind to two different antigens at the same time. Teclistamab binds to B-cell maturation antigen (BCMA), a protein found on some B-cells and myeloma cells, and CD3 on T-cells (a type of white blood cell) and may interfere with the ability of cancer cells to grow and spread. Giving teclistamab may be safe and tolerable in treating patients with recurrent or refractory plasmablastic lymphoma.
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