NCT07865377
Serum Endogenous Estrogens, Estrogen Receptors, and Sirtuin-1 and -3 After Resveratrol Supplementation
레지스트리 요약
- 진행 상태
- 모집중 (RECRUITING)
- 질환/조건
- Coronary Artery Disease (CAD), Menopause, Hormones
- 시험 유형
- 중재 연구 (INTERVENTIONAL)
- 단계
- 해당 없음(NA)
- 목적
- 예방
- 중재 유형
- 식이보충제, 기타
- 개입·치료
- Trans-resveratrol, 1000 mg daily for 90 days, Placebo
- Lead Sponsor
- InCor Heart Institute (기타)
캐시 시각: 2026-10-09 02:19:05
요약
Atherosclerotic coronary artery disease (CAD) is a leading cause of mortality among postmenopausal women. Resveratrol, a phenolic compound with antioxidant properties, may influence lipid metabolism, endothelial function, and platelet aggregation, while sirtuin-1 and sirtuin-3 regulate metabolic and hormonal responses to nutritional stimuli. This randomized, double-blind, placebo-controlled trial evaluates the effects of trans-resveratrol supplementation (1000 mg/day) versus placebo, over 90 days, on serum estradiol and estrone levels, gene expression of estrogen receptors alpha and beta, and sirtuins 1 and 3 in 80 postmenopausal women with CAD. Findings may inform therapeutic strategies for postmenopausal women with chronic coronary disease.
카카오 로그인 후 의뢰